I have done some testing with it, and I've found a noticeable difference on several cars. Some cars, I feel no difference between having chassis reinforce or not.
Some cars, like all of my Nissan S-Chassis, I find feel much better
without chassis reinforce. The rear of the car feels like it has quite a bit more grip. The downside to not having chassis reinforce is that the car feels slightly less responsive...almost sluggish in its lateral movements. I've found the best way to overcome this is to slightly increase anti-roll bar stiffness at both the front and rear. Some other cars I've experiemented with not doing chassis reinforce, and have had what I would classify as positive results, are the Nissan Z33, Nissan 300ZX, Toyota Aristo, Mercedes Benz C63, and a couple others I can't think of right now.
I've found other cars that feel terrible to me without chassis reinforce. These include, but are not limited to BMW M3 Coupé, Nissan 370GT Coupé, and Honda S2000. Without chassis reinforce, to me, these cars understeer and are unpredictable/unresponsive.
Based on the rather small amount of testing I have done in this area, I have come to this basic conclusion:
-cars that naturally understeer, have a lot of grip at the rear, and/or are slightly lower on the power scale, benefit from doing chassis reinforcement (ie M3 Coupé, 370GT, S2K)
-cars that naturally oversteer, have low rear grip (or just excessive wheelspin), and/or are higher on the power scale, tend to benefit from NO chassis reinforcement.
The cars where I've notice the bigges difference is in my S-Chassis. I used to have chassis reinforcement done to all of them (just out of habit). However, after doing some testing, based off of TwinTurboCH's S-Chassis tune, I discovered that these cars feel much better without it. The wheelspin feels much more controllable, and the cars feel like the accelerate out of a corner better, and the cars just overall feel faster ( speed is an important aspect of my tuning style...it's not for everyone, but it's how I get down
).
Hope this helps. I would love to see what others have to say about chassis reinforce as well