I am slowly proceeding through this game. It's my third play through. The first two were on the Xbone, this one is on PC.
I'm taking my time, because I have Modern Firearms installed, and enemies at higher levels than me tend to aim for head shots. The Gunner sergents and Captains are especially good at putting an end to the sole survivor with one shot. It doesn't help that they are packing sniper rifles with 400+ points of damage. Wowzers!
Then there's the Raiders. I installed a mod named(ill insert its name here when I get home), and it made the Raiders as tough as nails. I can kill them, but they take some effort. At least they have armor that can stand up to Modern Firearms' levels of abuse... Unless a head shot is involved. LOL.
I'm also running Super Mutant Redux. Let's just say, the Super muties are about as tough as Fist... All of them. Yeah. Good times. Oh and there's Nightkin included in the mod. Anyone that's played New Vegas knows what sort of headaches I am having with them.
Yup. This is one interesting play through.