So your problem is how they're made up rather than just the fact that they're made up, right?
Not entirely accurate. My problem is upon what basis one decides that a set of statements constitutes an accurate representation of reality. There are different levels of knowledge. Allow me to explain:
1) That you exist as the thinker of your thoughts
This is the most fundamental level. Only you can know this about reality and no other 100% pure knowledge can be determined to this level. You know that you exist, and that you exist in a form that is at least partially represented as the thinker of your thoughts. You might be a computer program running on a mainframe on an alien world, but whatever you are, you exist, and what you are is at least partially described as the thinker of your thoughts. The question "what if someone else is the thinker of my thoughts" is pointless, because that means you're them.
2) Logic (deductive reasoning)
Logic is the next most fundamental level. It is a set of tautologies - things that must be true by definition. If you assume A, and you assume the rule that A implies B, then you can conclude B. This much is self-fulfilling. The leap to logic is to apply any of these rules to your perceptions. There is always an acknowledged assumption about the property of the universe that you're applying logic to. For example: If gravity exists, and gravity implies that this object will orbit, then the object will orbit. We don't really know that gravity exists just as we don't know that the earth exists. We don't know that gravity will continue to exist in the future either... or the object for that matter. But
if they exist - even merely as perceptions, and they exist as they have in the past, then they will be have as described.
3) Mathematics / Human Rights
These are derived from logic, the 2nd most well understood characteristic of reality. I only put them below #2 because they are derivations, really they are #2, because all derivations are is the set of rules from which they are derived.
4) Science (inductive reasoning)
Science is merely a collection of theories (models) that describe all available evidence (data). Think of science as a best-effort explanation that is required to fit an amazing set of data (all available data ever recorded). Science fits only the evidence that we have, so more evidence can require science to change. This means that whatever theory (model) science puts forth, it might have to be adjusted in the future. Science is an approximation of reality. As we better observe and discover reality, that approximation will change. Science should not be regarded as truth, but rather as an estimate. Questioning science requires questioning the data set that the science is based on. Sometimes that's easy (not much data), and sometimes it's very very hard (lots of data).
5) Probability
This is the assumption that reality will behave in a certain way because, even though inductive reasoning would tell you that it is possible that it will not behave in that way, such an outcome rarely occurs. This is, for example, the "knowledge" that when you get in your car and go to work that you will make it to work alive. It isn't actually knowledge, you may die during that trip, but you act as though it is knowledge because you estimate the chances of dying on your way to work to be low. Think of this as a form of science that gets to ignore the rare data points. In otherwords, science without the scientific method being adhered to.
6) Guesswork
This is an attempt to describe some aspect of reality with only one piece of the data set - your immediate perceptions. An example of this would be when you decide to go see a movie. You see a movie trailer or poster (that's your data set to determine whether you will like the movie). You know that your data is biased (they want to sell it to you) and you attempt to adjust for that based on some unknown criteria (a guess at how biased it is). Then, using only that limited data set which you know is flawed, you draw a conclusion that you barely have any hope of defending - which is that you have a reasonable chance of liking the movie and that it is worth the currency that it is going to cost. This is guesswork. You do this when being wrong doesn't hurt very much.
Religion is number 6.