Technically, some might have done under the guise of the 1950-1960 Indy 500s.
I do know the first front-wheel drive win at Indy was in 1925, I believe.
As to a non-Indy 500 front-wheel drive Formula One entry, that is trickier.
Was it the 1957 German Grand Prix which was open to both F1 and F2 cars?
Sorry for not getting back to this earlier in the week, but here's my question:
At this year's Belgian GP, Andre Lotterer joined a very unenviable club. Which club is that, and who else is in it?
I just checked the results and according to them Loetterer drove 1 lap.I'll be honest, I'm not sure whether Lotterer completed the first lap or not. However, since @Liquid named a driver who also failed to finish a single lap of any GP which they started, it's his go next.
1958 in Monza?