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The biblical interpretation of that, at least in a literalist sense, traces back to the story of the Tower of Babel, where God is said to have split the nations into differing groups speaking different tongues, so they could never again coordinate an effort so huge as to build a tower attempting to reach God. Apparently he found this to be an affront... personally I think I'd get a bit lonely up there, and some company might be nice.
To quote Stewie Griffin,
"I LOVE this God fellow! He's so deliciously evil!"
I'm just wondering how tall this building must have been to freak God out. He doesn't seem particularly bummed about astronauts, or BAC Lightning pilots, who frequently described their aircraft as being able to "climb like a homesick angel".