Yeah less wing will take some pressure off the tyres, but it can backfire, as the back end will slide around easier. Thermal deg is the quickest way to ruin the tyres. Less wing can lower the load on the tyres, but you'll end up understeering or oversteering, or sometimes a combination of the two lol. Keep the temp graphic up while you practice, and you'll see how badly the tyres will overheat. The best way I found is to reduce your mechanical grip with less camber and toe, and your tyres will retain less heat. Also for some reason having lower tyre pressures makes them heat up slower (which is backwards), so use that too. You'll lose a fair bit of mechanical grip, but you can reclaim lap time with more aero grip.
Watch the weather, if it's going to be a hot session, go for less camber/toe/tyre pressure, and more wing to compensate. You should be able to significantly reduce your tyre wear if you do it right. My set ups are always a compromise between ultimate one lap pace and tyre wear. Obviously in a cold session, or rain, you'll want the car set up to keep the heat in the tyres, so more camber and toe can be used.
As far as aero balance, it really depends on car. The Mclaren will handle however you want it to, so that one will handle low rear wing high front no dramas. The Force Inidia, on the other hand, has a large tendency to oversteer, and also eats it's rear tyres if you aren't careful. This means the difference between front and rear wing can't be so big, which is a pain, as it'll understeer on new tyres, and then half way through the tyre life, it's hard to keep the rears planted. If you go for an oversteering set up, it'll be quick in quali, but your tyres will be ruined half way through a stint, and it'll be a handful to make it to your pit window.
I haven't driven the Ferrari, Mercedes, or Red Bull yet, but I have a feeling they'll all have nice chassis, so you'll have a bigger set up window to make the car work how you want it to. The Mclaren is like that, but the gutless engine really lets it down.
If your car is set up for great one lap pace, but you're finding you have to make an extra stop, it's not so bad. You can make that work at a fair few tracks. I was doing that in the Williams, and I reckon 75% of the times I tried it, I was finishing in a higher position than I would have if I had saved tyres and gone for the same strategy as the AI.
The Mclaren was great on tyres, my team mate was sometimes stopping once less than most other AI cars. I went full on aggressive with it every race, set up wise, and sometimes needed to do one more stop than the AI. On Legend, I finished the season 6th as Button. I won 2 or 3 races and took a few more podiums. One race, I think it was Sochi, Alonso did a one stop, while the other AIs did a two stop, and I did a three stop, because my set up was a full on quali set up. I finished the race, despite it being largely a power track, in 3rd place, and a full lap ahead of Alonso. So it's definitely possible to make multiple strategies work in some races. The trick, I've found, is to try and pick which races you'll be able to make it work, and which one's it'll be too hard to make work. Give it a go at tracks that'll suit your car's style. Tracks where you'll be struggling anyway, you're best off going for the standard strategy and taking it easy on the tyres.