I think the Predators just might upset the Red Wings in 7, but it'll be a really tough series for both teams. I wouldn't be surprised to see the Canucks go deep again (particularly with the addition on Pahlsonn, Kesler won't have to be worn down as much by shadowing the best players on the other teams). If I were to pick a cup favourite, it would be Pittsburgh, assuming that Fleury is OK (he left the game vs the Islanders tonight after a collision with a forward on his own team).
The Penguins are just so deep. The only place that is a bit of a weakness is on D, where they aren't top 3 in the league but are still a good D corps. Fleury is a good goalie, IMO he's overrated but can certainly get the job done. And any team playing against the Penguins shouldn't have to worry about the Penguins PP, as it will generally be over in about 6 or 7 seconds. (Joke stolen from downgoesbrown.com)
I just think with the monster season Malkin's had, and Crosby coming back free from the wear and tear of a season, look out. I can't see anyone other than Boston beating them out of the East, although as a Habs fan we definitely proved anything's possible a couple years back.
I dunno, out of the West I'd say Vancouver, or Nashville, potentially St. Louis if Halak resembles a 4 by 6 brick wall again. Out of the East, Pittsburgh, or Boston for the repeat (oh god please no).