An engine is most efficient at peak torque (heh, kinda obvious in a way). So you'd want to put energy into the car's movement only around peak torque, and only at full throttle.
That means operating within a certain percentage of the peak efficiency at the lowest possible speed (to minimise all kinds of drag), which means the lowest gear. So if peak torque is at 4000 rpm, and it drops to, say, 80% at, say, 2500 and 4750, then you start at 2500, accelerate to 4750 and shut the engine off until the road speed would give you 2500 rpm again, then start the engine through the wheels (potentially more efficient, electronics permitting) and repeat.
Of course, you probably can't turn the engine off in GT6, so it'd have to be something else. Namely, cruising at the engine speed that gives you the best brake-specific-fuel-consumption for the required throttle opening (iterative testing required) and in the lowest gear that's achievable - certainly for a start. But I doubt GT actually has realistic BSFC curves...